What does positive for CK7 mean?

For example, a CK7-negative/CK20-positive phenotype is often associated with carcinomas of colorectal origin, whereas a CK7-positive/CK20-negative phenotype is seen in a wide variety of carcinomas, including carcinomas of the lung, breast, thyroid, pancreas, and female genital tract.

What does CK7 mean in cancer?

Cytokeratin 7 (CK7) is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract. 305,306. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7. 307-309.

What is the function of CK7?

Because the keratin-7 antigen is found in both healthy and neoplastic cells, antibodies to CK7 can be used in immunohistochemistry to distinguish ovarian and transitional cell carcinomas (staining positive) from colonic and prostate cancers (negative), respectively.

What is CK7 positive in lung cancer?

CK7 can be specifically expressed in certain cancers, which has been verified to be expressed in lung cancer of the present study; besides, the expression of CK7 is a sign of dedifferentiation, positive cells of CK7 may therefore be relatively lower differentiation cells with high degree of malignancy.

What does acinar predominant mean?

IMAs were divided into lepidic-predominant and acinar-predominant IMA, according to the growth pattern of tumor cells. Lepidic-predominant and acinar-predominant IMAs are defined as having a lepidic or an acinar pattern of more than 50\%.

Where is CK7 found?

CK7 is found in the glandular epithelium and epithelial tumors of lung, ovary, endometrium and breast, but is not found in GI epithelium. Conversely, CK20 is expressed principally in the normal glands and epithelial tumors of the GI tract, urothelium, and Merkel cells.

What does cytokeratin stain for?

Cytokeratin filaments are located within the cytoplasm of cells. Thus, cytokeratin immunostains should be cytoplasmic stains. Cytokeratin immunostains will stain most carcinomas, carcinoid tumors, epithelial organs, etc. Useful in differentiating sarcomatoid carcinoma from sarcoma.

Is CK7 positive in mesothelioma?

Furthermore, CK7 negativity most often is associated with metastases, and the CK20+/7- pattern, typical of colorectal adenocarcinomas, is absent in pleural mesotheliomas.

What does CK7 stain?

Cytokeratin 7 (CK7) is a type II basic low molecular weight cytokeratin that is found in simple epithelia in a variety of organs, including all epithelia in the female genital tract. Epithelial tumors of the ovary and fallopian tube all exhibit cytoplasmic and/or membrane staining for CK7.

Is CK7 positive in squamous cell carcinoma?

CK5 is also highly specific for squamous cell carcinoma. Although CK20 positivity may be seen in pulmonary adenocarcinomas—in combination with negative staining for TTF1 and NAPA in rare cases—CK7 is always positive.

What does ck5 6 positive mean?

Cytokeratin 5/6 is a positive marker for malignant pleural mesothelioma, found in more than three-fourths of cases. It is also found in certain types of lung cancers and breast cancers. Pathologists use cytokeratin 5/6 to stain cancer tissue samples.

What is cytokeratin 7 (CK7)?

Cytokeratin 7 (CK7 or keratin 7) is a type of protein that forms the intermediate filaments that provide structure and support for human (and other mammalian) epithelial cells. Antibodies to this protein have been developed and are commercially available to be applied to human tissues by a process called immunohistochemical staining.

What are the drawbacks of cytokeratin staining?

One of the drawbacks of cytokeratin staining is that tumours may stain for both CK7 and CK20. In our study population, while most tumours stained positive for either CK7 or CK20, there was one case (4\%) of primary lung cancer and one case (4\%) of metastatic deposit in the small bowel from a known colorectal cancer,…

What is the role of cytokeratin in the diagnosis of lung adenocarcinoma?

Thyroid transcription factor-1 (TTF-1), and cytokeratin 7 (CK7) and cytokeratin 20 (CK20) have recently been reported to be useful to distinguish between primary and metastatic lung adenocarcinoma.

What is the difference between CK7 and CK20 staining?

They observed CK7 expression in the majority of lung, breast, endometrium, ovary, cervix, salivary gland, thyroid cancers, cholangiocarcinoma, and adenocarcinoma of the pancreas. In contrast, CK20 staining was seen in all colorectal adenocarcinomas and in the majority of gastric, pancreatic, and Merkel cell tumours.