Are all SSRIs CYP2D6 inhibitors?

Most SSRIs are deactivated by CYP2D6; thus, CYP2D6 PMs are at elevated risk for SSRI overdose, which can result in drowsiness, tremor, nausea, vomiting, seizures, and coma. Therefore, administration of SSRIs in PMs and IMs should be approached with caution.

What antidepressants are metabolized by CYP2D6?

CYP2D6 is involved in the metabolism of most antidepressants, and is primarily responsible for breakdown of amitriptyline, venlafaxine, fluoxetine and paroxetine among others. This enzyme also contributes to the metabolism of other antidepressants such as citalopram, duloxetine and mirtazapine.

Is Zoloft a CYP2D6 inhibitor?

Sertraline, a selective serotonin reuptake inhibitor used to treat depression, inhibits CYP2D6 in vitro (Ki = 1.2 microM) less potently than fluoxetine (Ki = 0.15 microM).

Is citalopram a CYP2D6 inhibitors?

According to in vitro and in vivo studies, citalopram and escitalopram appear to have minimal effects on major CYP enzymes [Articles:10507506, 12387707] Citalopram is a weak CYP2D6 inhibitor and has weak or no effects on CYP1A2, CYP2C19, and CYP3A4 [Article:18691982].

Does Lexapro inhibit CYP2D6?

Other antidepressants are weaker inhibitors of CYP2D6, such as citalopram (Celexa), escitalopram (Lexapro), desvenlafaxine (Pristiq), and sertraline (Zoloft). Although they are probably preferable to the more potent CYP2D6 inhibitors, theoretically they might inhibit tamoxifen in some patients.

Which SSRI has least drug interactions?

Sertraline, citalopram and escitalopram have the lowest potential for drug interactions among the SSRIs, and are to be preferred in patients on other drugs for general medical conditions or if consideration is given to adding an SSRI to other psychotropic medication.

Does Wellbutrin inhibit CYP2D6?

Bupropion is therefore a potent inhibitor of CYP2D6 activity, and care should be exercised when initiating or discontinuing bupropion use in patients taking drugs metabolized by CYP2D6.

Does amitriptyline inhibitor CYP2D6?

TCAs such as amitriptyline are also metabolised by CYP2D6. Fluoxetine will inhibit this and increase plasma concentrations of the TCA and increase dose related adverse effects. The activity of codeine is mainly due to conversion to morphine by CYP2D6.

Does Prozac inhibit CYP3A4?

Fluoxetine (Prozac®) is a widely prescribed antidepressant, but is also a potent inhibitor of cytochrome P450 (CYP) enzymes. From in vitro data, fluoxetine is predicted to be a moderate inhibitor of CYP2D6, but a strong inhibitor of CYP2C19 and CYP3A4.

Does sertraline inhibit CYP3A4?

These results suggest that sertraline is a mechanism- based inhibitor of CYP3A4.

Is fluoxetine a CYP2D6 inhibitor?

From in vitro data, fluoxetine is predicted to be a moderate inhibitor of CYP2D6, but a strong inhibitor of CYP2C19 and CYP3A4.

Is amitriptyline a CYP2C19 inhibitor?

The CYP2C19 enzyme contributes to the metabolism of a range of clinically important drugs, such as several proton pump inhibitors, clopidogrel, benzodiazepines, and several tricyclic antidepressants, including amitriptyline.

Which antidepressants are CYP2D6 inhibitors?

Other antidepressants are weaker inhibitors of CYP2D6, such as citalopram (Celexa), escitalopram (Lexapro), desvenlafaxine (Pristiq), and sertraline (Zoloft). Although they are probably preferable to the more potent CYP2D6 inhibitors, theoretically they might inhibit tamoxifen in some patients.

What medications interfere with CYP2D6 metabolism?

At a minimum, particular care should be exercised with the SSRIs fluoxetine and paroxetine, which are metabolized by and inhibit CYP2D6.

Does Benadryl (diphenhydramine) inhibit CYP2D6?

Some OTC antihistamines such as diphenhydramine (Benadryl) inhibit CYP2D6, so one may not be able to rely on computerized drug interaction screening systems (which may not contain OTC medications) to catch all CYP2D6 inhibitors in patients on tamoxifen.

Is there a CYP2D6 inhibitor that will inhibit tamoxifen?

Although they are probably preferable to the more potent CYP2D6 inhibitors, theoretically they might inhibit tamoxifen in some patients. Venlafaxine (Effexor) seems to have little or no effect on CYP2D6. Other drugs that inhibit CYP2D6 can be found in the Table.