Are there different types of TNBC?

Triple-negative breast cancer (TNBC) has been subdivided into six distinct subgroups: basal-like 1 (BL1), basal-like 2 (BL2), mesenchymal (M), mesenchymal stem–like (MSL), immunomodulatory (IM), and luminal androgen receptor (LAR).

What does aggressive breast cancer mean?

Background: Aggressive breast cancer is a term commonly used in literature to describe breast cancer with a poor prognosis. Identifying and understanding the factors associated with aggressiveness could be helpful to the management of patients with breast cancer.

What is metastatic TNBC?

Triple-negative breast cancer (TNBC) accounts for about 10-15\% of all breast cancers. The term triple-negative breast cancer refers to the fact that the cancer cells don’t have estrogen or progesterone receptors (ER or PR) and also don’t make any or too much of the protein called HER2.

Can DCIS be triple negative?

Ductal carcinoma in situ (DCIS) is defined as a non-invasive overgrowth of cells characterized by high proliferation within the breast ductal system. Studies suggest that triple-negative DCIS (TN-DCIS), a rare type of DCIS, is a precursor stage of invasive breast cancer5,6.

What is the prognosis for aggressive breast cancer?

The average 10-year survival rate for women with non-metastatic invasive breast cancer is 84\%. If the invasive breast cancer is located only in the breast, the 5-year survival rate of women with this disease is 99\%.

Is aggressive breast cancer curable?

With aggressive treatment, stage 3 breast cancer is curable; however, the risk that the cancer will grow back after treatment is high.

Does TNBC always come back?

TNBC has a high recurrence rate, which is greatest within the first 3 years. However, there’s a sharp reduction in recurrence after 5 years. Therefore, there are no long post-therapy regimens. People with early stage TNBC generally have a shorter treatment course compared to other subtypes.

How fast does aggressive breast cancer grow?

According to the Robert W. Franz Cancer Research Center at Providence Portland Medical Center, breast cancer cells need to divide at least 30 times before they are detectable by physical exam. Each division takes about 1 to 2 months, so a detectable tumor has likely been growing in the body for 2 to 5 years.

How aggressive is TNBC?

Triple-negative breast cancer (TNBC) is considered an aggressive cancer because it grows quickly, is more likely to have spread at the time it’s found, and is more likely to come back after treatment than other types of breast cancer. The outlook is generally not as good as it is for other types of breast cancer.

What is the life expectancy of someone with triple negative breast cancer?

In general, about91\% of all women with triple-negative breast cancer are still alive 5 years after diagnosis. If the cancer has spread to the lymph nodes near the breast (regional) the 5 year relative survival rate is about 65\%. If the cancer has spread to distant places, the 5 year relative survival rate is 11\%.

What causes triple negative breast cancer?

One of the leading causes of triple-negative is a woman’s genetic makeup, specifically the BRCA1 and BRCA2 genes, which are genes that are supposed to produce tumor suppressant proteins in the body.