Do antidepressants reduce the effectiveness of tamoxifen?

A recent study published in the British Medical Journal provides evidence that antidepressants which are potent inhibitors of CYP2D6 enzymes may decrease the effectiveness of tamoxifen and may result in worse outcomes.

Does Prozac interfere with tamoxifen?

Caution should be used when it is taken along with antidepressant medications, as some of them interfere with the way tamoxifen works at decreasing the risk of breast cancer recurrence. Antidepressants such as Paxil or Prozac should be avoided, while others, such as Celexa or Lexapro, may be a safer option.

Are antidepressants linked to breast cancer?

There is epidemiological evidence that antidepressant (AD) medication use may be associated with an increased risk of breast cancer in women,1–5 although findings have been inconsistent, with three studies reporting no association6–8 and five other studies finding an increased risk of breast cancer in women taking …

What medications interfere with tamoxifen?

The medications under the heading “Not Inhibitors” do not block the CYP2D6 enzyme and will not interfere with tamoxifen treatment….Medicines to avoid while taking tamoxifen.

Strong Inhibitors
Fluoxetine	Prozac
Paroxetine	Paxil
Quinidine	Cardioquin
Thioridazine	Mellaril

Does fluoxetine increase estrogen?

Results: Fluoxetine significantly increased estradiol secretion in H295R cells after a 48h exposure at low, submicromolar concentrations, but showed no effects on testosterone levels or aromatase mRNA expression.

What are the safest antidepressants to take?

Citalopram and escitalopram have been considered the safest among the SSRIs with respect to potential for liver injury [41].

Does FLUoxetine increase estrogen?

Does Paxil increase estrogen?

They found that paroxetine, the ingredient in the popular antidepressant Paxil, alters the activity of estrogen, and they released their results in February 2014. In short, it is clear that paroxetine has an “estrogenic effect” that could play a role in promoting the development and growth of tumors.

Can Prozac cause breast cancer?

There were no associations between other types of antidepressant classes and breast cancer risk. In assessing risks among the five most commonly used antidepressants, we detected no association with fluoxetine, sertraline, venlafaxine or buproprion hydrochloride.

Do SSRIs increase risk of cancer?

Over the past decades, there have been several studies that have evaluated the possible association between SSRIs and cancer risk. Earlier studies suggested that SSRIs increased the risk of cancer, especially breast cancer and colorectal cancer [4,5,6,7].

Does Prozac increase breast cancer risk?

Antidepressants-Paxil, Prozac, Zoloft Increase Risk of Breast Cancer May 31, 2009 An independent large study conducted by MEDCO Health Solutions Inc. found that women treated with tamoxifen for breast cancer doubled the risk of the disease returning if they used antidepressants–in particular, Paxil and Prozac.

The new study, reported Saturday at a cancer conference in Florida, is the largest to look at the issue. It found that using these interfering drugs – including Prozac, Paxil or Zoloft – can virtually wipe out the benefit tamoxifen provides.

Should breast cancer survivors take antidepressants while taking tamoxifen?

ORLANDO, Fla. (AP) — Breast cancer survivors risk having their disease come back if they use certain antidepressants while also taking the cancer prevention drug tamoxifen, worrisome new research shows. About 500,000 women in the United States take tamoxifen, which cuts in half the chances of a breast cancer recurrence.

Should the FDA add a warning label to tamoxefin and Paxil?

Inexplicably, the FDA has dragged its feet about adding a warning label to both tamoxefin and the antidepressants, Paxil, Prozac and Zoloft–despite the unanimous recommendation of its own advisory panel in 2006.