How are the intrinsic and extrinsic coagulation pathways similar?

The intrinsic pathway is activated through exposed endothelial collagen, and the extrinsic pathway is activated through tissue factor released by endothelial cells after external damage. This pathway is the longer pathway of secondary hemostasis.

Which factor do both extrinsic and intrinsic pathway have in common?

Both intrinsic and extrinsic pathways meet at a shared point to continue coagulation, the common pathway. Clotting factors involved in the intrinsic pathway include factors XII, XI, IX, and VIII. Clotting factors involved in the extrinsic pathway include factors VII, and III.

What is the first clotting factor that the extrinsic and intrinsic pathways have in common?

Factor XII is considered the coagulation factor first activated in the intrinsic pathway. Upon activation, XIIa acts upon factor XI, and the cascade proceeds through factor IX to also activate factor X to trigger the common pathway.

In what ways do the intrinsic and extrinsic pathways of the clotting cascade differ?

Intrinsic pathway is one type of blood coagulation pathway that is activated when there is a blood trauma. Extrinsic pathway is a type of blood coagulation pathway that is activated when the traumatized vascular wall or the extra-vascular tissues come into contact with the blood. Intrinsic Pathway is slow.

What is the main difference between the extrinsic and the intrinsic pathways?

The main difference between intrinsic and extrinsic pathways in blood clotting is that intrinsic pathway is activated by a trauma inside the vascular system whereas extrinsic pathway is activated by external trauma.

What is the difference between intrinsic and extrinsic apoptosis?

The extrinsic pathway of apoptosis begins outside a cell, when conditions in the extracellular environment determine that a cell must die. The intrinsic pathway of apoptosis pathway begins when an injury occurs within the cell and the resulting stress activates the apoptotic pathway.

How do the extrinsic and intrinsic coagulation pathways lead to the common pathway?

Both the intrinsic and extrinsic pathways lead to the common pathway, in which fibrin is produced to seal off the vessel. Once factor X has been activated by either the intrinsic or extrinsic pathway, the enzyme prothrombinase converts factor II, the inactive enzyme prothrombin, into the active enzyme thrombin.

Where do the intrinsic and extrinsic pathways converge?

Both the intrinsic and extrinsic pathways converge in the formation of factor Xa. The stages that follow are common to both pathways. Factor Xa converts prothrombin into thrombin. This reaction is accelerated by factor Va.

Why is it called intrinsic and extrinsic pathway?

“Intrinsic” sounds like the important pathway that happens in the body, and “extrinsic” sounds like one that might happen in the lab, or outside the body. The two pathways were named that way because of the way blood clots in a test tube in the lab – not because of the way the pathways act in the body.

How do you remember intrinsic and extrinsic pathways?

Coagulation cascade is activated by 2 pathways, the extrinsic and intrinsic which culminates into a common pathway. The factors involved in common pathway can be remembered by a mnemonic: 1 X 2 X 5 = 10. 3.

Which protein is common to both the intrinsic and extrinsic pathway of apoptosis?

In both the intrinsic and extrinsic pathway of apoptosis, signaling results in the activation of a family of Cys (Cysteine) proteases, named caspases, that act in a proteolytic cascade to dismantle and remove the dying cell (1).

What is the common pathway of coagulation?

Coagulation can be initiated through the activation of two separate pathways, designated extrinsic and intrinsic. Both pathways result in the production of factor X. The activation of this factor marks the beginning of the so-called common pathway of coagulation, which results in the formation of a clot.

What are intrinsic and extrinsic factors?

Intrinsic Factors.

What is intrinsic pathway?

In molecular biology, the term intrinsic pathway may refer to multiple cascades of protein interactions. The intrinsic pathway of apoptosis refers to cell death initiated by changes in mitochondria, also known as the mitochondrial pathway or intracellular pathway or intrinsic apoptosis.

What is intrinsic and extrinsic clotting?

The difference between intrinsic and extrinsic pathways in blood clotting depends on their initiation factors; extrinsic pathway is initiated after the release of a tissue factor to the blood due to a trauma to the vascular wall or surrounding tissues while intrinsic pathway is initiated when collagen contacts with the blood due to blood trauma.