How does Yersinia pestis cause death?

When bubonic plague is left untreated, plague bacteria can invade the bloodstream. When plague bacteria multiply in the bloodstream, they spread rapidly throughout the body and cause a severe and often fatal condition called septicemic plague.

How Yersinia pestis causes disease?

Plague is a disease that affects humans and other mammals. It is caused by the bacterium, Yersinia pestis. Humans usually get plague after being bitten by a rodent flea that is carrying the plague bacterium or by handling an animal infected with plague.

How does Yersinia pestis affect the body?

pestis infection in the lungs. Symptoms include high fever, chills, headaches, chest pain, rapid breathing, severe shortness of breath and cough that might bring up blood. Without proper treatment, the disease can quickly lead to death.

What does Yersinia pseudotuberculosis cause?

pseudotuberculosis causes self-limiting acute gastroenteritis and mesenteric lymphadenitis that mimics acute appendicitis. Enteritis is usually seen in children as opposed to the mesenteric adenitis seen in adults. [5] Symptoms include abdominal pain, fever, vomiting, and diarrhea.

Is Yersinia pestis the Black Death?

Plague is caused by Yersinia pestis bacteria. It can be a life-threatening infection if not treated promptly. Plague has caused several major epidemics in Europe and Asia over the last 2,000 years. Plague has most famously been called “the Black Death” because it can cause skin sores that form black scabs.

How does Yersinia pestis damage host cells?

pestis against host phagocytes of the innate immune system, thereby allowing it to invade more tissues and organs and cause more severe impairment. Y. pestis carries both invasive factors, which promote contact with and entry into host cells, and antiphagocytic factors that inhibit uptake by host cells.

What are the complications at pseudotuberculosis and enteric Yersiniosis?

Complications of Y pseudotuberculosis infection may include intussusception, bacteremia, septic arthritis, and disseminated infection, especially in immunocompromises or iron-overloaded patients.

What is the main factor in pathogenesis of a pseudotuberculosis?

The enteropathogen, Yersinia pseudotuberculosis, requires a large inoculum to produce the disease. The primary virulence factor is a plasmid-encoded protein that causes increased invasiveness.

How does Yersinia pestis move?

When the bacteria is in a host, it is nonmotile (incapable of self-propelled movement), but when isolated it is motile (1). Y. pestis uses aerobic respiration and anaerobic fermentation to produce and consume hydrogen gas for energy.

What is Yersinia pestis made of?

Yersinia pestis (Y. pestis) (formerly Pasteurella pestis) is a gram-negative, non-motile, coccobacillus bacterium without spores that is related to both Yersinia pseudotuberculosis and Yersinia enterocolitica. It is a facultative anaerobic organism that can infect humans via the Oriental rat flea (Xenopsylla cheopis).

What was the deadliest plague?

Black Death: 75-200M (1334-1353) In 1346 it struck a trading port called Kaffa in the Black Sea. Ships from departing Kaffa carried trade goods and also carried rats, who carried fleas, who carried Yersinia Pestis. In October 1347, 12 such ships docked at Messina in Sicily, their hulls full of dead and dying sailors.