How is Sumatriptan metabolized?

Sumatriptan is metabolised primarily by monoamine oxidase A into 2-{5-[(methylsulfamoyl)methyl]-indole-3-yl}acetic acid, which is then conjugated to glucuronic acid. These metabolites are excreted in the urine and bile. Only about 3\% of the active drug may be recovered unchanged.

How does Sumatriptan affect serotonin?

Sumatriptan works by binding to serotonin 5‑HT1B/1D receptors and is thought to relieve migraine symptoms through inhibition of pro-inflammatory substances and a constriction of cranial blood vessels. Sumatriptan belongs to the class of medicines known as selective serotonin receptor agonists.

How does Imitrex work in the body?

Triptans like Imitrex work by stimulating serotonin receptors (docking stations) found on blood vessels in the brain. This causes these blood vessels to narrow, which helps relieve the migraine or cluster headache. Imitrex may also block activity in the trigeminal nerve.

Does sumatriptan affect the liver?

Sumatriptan (applies to Imitrex) liver disease Major Potential Hazard, High plausibility.

How long does sumatriptan stay in your system?

How long do sumatriptan side effects last? Sumatriptan is a short-acting medication with a half-life of around two hours. A sumatriptan dose will be completely cleared from the body in 10 hours.

Is sumatriptan a stimulant?

Sumatriptan works by stimulating serotonin receptors in the brain, which causes the muscles surrounding the blood vessels in the brain to contract. Sumatriptan also stabilises some of the chemical changes in the brain during a migraine attack, which alleviates migraine symptoms.

Does sumatriptan have caffeine?

Welcome to MyMigraineConnection! None of the Migraine abortive medications have caffeine in them: Triptans: Imitrex, Maxalt, Zomig, Amerge, Relpax, Axert, Frova. Imitrex is now available as the generic sumatriptan or combined with naproxen sodium in Treximet.

Why does my body hurt after taking sumatriptan?

These results suggest that mild vasoconstriction in peripheral skeletal muscle is associated with the action of sumatriptan and is likely to be the source of the side-effects experienced by some users.

Does Imitrex have caffeine in it?

Can sumatriptan damage kidneys?

Kidney function: The effect of reduced kidney function on how sumatriptan acts in the body has not been evaluated. Sumatriptan is not recommended for use if you have reduced kidney function. Liver function: Liver disease or reduced liver function may cause this medication to build up in the body, causing side effects.

How are triptans metabolized?

Generally, the triptans are metabolized by phase I monoamine oxidases (MAOs) and by various cytochrome p450 enzymes. However, each triptan has a unique metabolic profile, leading to significant differences in each triptan’s potential for drug-drug interactions.

When should I take sumatriptan If I have a migraine?

Even if you get warning signals of a coming migraine (an aura), you should wait until the headache pain starts before using sumatriptan. Ask your doctor ahead of time about any other medicine you might take if sumatriptan does not work. After you use the other medicine, check with your doctor as soon as possible.

What happens if you take too much sumatriptan?

Overuse of sumatriptan and other acute migraine drugs may lead to medication overuse headache (symptoms include daily headaches or a marked increase in migraine frequency). Symptoms of a stroke or TIA may be easily mistaken for those of a migraine.

What kind of drug is sumatriptan?

It belongs to a group of medicines called triptans, or serotonin (5-HT1) agonists. You take sumatriptan once a migraine or cluster headache has started.

What is sumsumatriptan used for?

Sumatriptan is a medication that helps to reduce or relieve migraine symptoms in some patients. It joins to receptors that normally bind to a chemical called serotonin and causes the constriction of dilated blood vessels as a result. A common brand of the medication is Imitrex.