What does lymphocytic infiltrate mean?

Lymphocytic infiltrate of Jessner is a rare skin condition that may be characterized by non-cancerous (benign) buildup of white blood cells, which present as lesions or lumps on the skin.

What causes lymphocytic infiltration?

What causes Jessner lymphocytic infiltrate? The cause of Jessner lymphocytic infiltrate is unknown. It is classified as a benign T-cell lymphoproliferative disorder. Some cases have been associated with Borrelia infection, the cause of Lyme disease.

Where is germinal center?

Germinal centers or germinal centres (GCs) are transiently formed structures within B cell zone (follicles) in secondary lymphoid organs – lymph nodes, ileal Peyer’s patches, and the spleen – where mature B cells are activated, proliferate, differentiate, and mutate their antibody genes (through somatic hypermutation …

What is germinal center type?

Germinal centers (GC) are transient and dynamic structures that form within lymphoid follicles upon antigen challenge. 1 Antigen‐activated GC B cells undergo rapid proliferation and somatic hypermutation of their immunoglobulin variable genes in order to generate high‐affinity B‐cell receptors (BCR).

What is the meaning of lymphocytic?

Lymphocytic: Referring to lymphocytes, a type of white blood cell. For example, lymphocytic inflammation in the skin is skin that is infiltrated with ‘lymphocytes.

What does lymphocytes mean in medical terms?

(LIM-foh-site) A type of immune cell that is made in the bone marrow and is found in the blood and in lymph tissue.

What causes germinal center formation?

Abstract. During a T-dependent immune response, activated B cells enter structures called germinal centers (GCs) in the follicles of secondary lymphoid organs. GC B cells proliferate and undergo diversification of their immunoglobulin (Ig) through somatic hypermutation and class-switch recombination.

What is germinal center formation?

The germinal center (GC) is a specialized microstructure that forms in secondary lymphoid tissues, producing long-lived antibody secreting plasma cells and memory B cells, which can provide protection against reinfection. A productive GC response requires the collaboration of multiple cell types.

What happens in a germinal Centre?

Key Points. The germinal centre (GC) of lymphoid organs is the main structure where antigen-activated B cells diversify their immunoglobulin genes by somatic hypermutation (SHM) to generate high-affinity antibodies.

What happens when lymphocytes are high?

High lymphocyte blood levels indicate your body is dealing with an infection or other inflammatory condition. Most often, a temporarily high lymphocyte count is a normal effect of your body’s immune system working. Sometimes, lymphocyte levels are elevated because of a serious condition, like leukemia.

What is the pathophysiology of lymphocytic infiltration?

Lymphocytic infiltration is mostly due to cytotoxic T-lymphocyte cells that cause anterior pituicyte destruction and fibrotic replacement with fibrosis.

What is the germinal center of the immune system?

Germinal center: The site where antigen-presenting cells interact with naïve B-cells to initiate an antigen-specific immune response. It is the slightly paler circular area within the secondary lymphoid follicle (Figure 1) and is composed predominantly of B cells, with rare T-cells and scattered support cells.

What is Jessner lymphocytic infiltration of the skin?

Jessner lymphocytic infiltrate of the skin is an uncommon disorder that is characterized by benign accumulations of lymph cells in the skin.

What is lymphocytic infiltration in endometriosis?

Lymphocytic Infiltration. Lymphocytic infiltration is mostly due to cytotoxic T-lymphocyte cells that cause anterior pituicyte destruction and fibrotic replacement with fibrosis.