What is Aria disease?

Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain of Alzheimer’s disease patients, associated with amyloid-modifying therapies, particularly human monoclonal antibodies such as aducanumab.

What is aria in Alzheimers?

Amyloid-related imaging abnormalities (ARIA) have been reported in Alzheimer’s disease (AD) patients treated with bapineuzumab, a humanized monoclonal antibody to amyloid-β. ARIA includes MRI signal abnormalities suggestive of vasogenic edema and sulcal effusions (ARIA-E) and hemosiderin deposits (ARIA-H).

What is Aria side effect?

The most common side effects include amyloid-related imaging abnormalities (ARIAs) — brain swelling or bleeding that usually do not cause symptoms. These side effects can be detected by MRI scans and often resolve over time.

Does the FDA approve Aducanumab?

On June 7, 2021, the US Food and Drug Administration (FDA) approved aducanumab (Aduhelm; Biogen Inc), the first new drug for the treatment of Alzheimer disease in 2 decades.

How do I know if my aria-label is working?

You can turn on NVDA’s speech viewer tool (ins+n > tools > speech viewer) and you can see what is being spoken. VoiceOver has a “closed captions” type viewer so you can see what’s being announced. Your aria-labels will be read by the screen reader.

Is there an association between aria-E and Aria-H?

CONCLUSIONS: In 49\% of cases of ARIA-E, there was the associated appearance of ARIA-H. In treated patients without ARIA-E, the risk for incident blood products was 4\%. This association between ARIA-E and ARIA-H may suggest a common pathophysiologic mechanism.

What is incident Aria-H?

Incident ARIA-H was determined by the detection of any blood products noted as new hypointense lesions on the blood-sensitive gradient recalled-echo/T2*-weighted imaging sequence.

What is Aria-H in a CT scan?

ARIA includes ARIA-E, parenchymal or sulcal hyperintensities on FLAIR indicative of parenchymal edema or sulcal effusions, and ARIA-H, hypointense regions on gradient recalled-echo/T2* indicative of hemosiderin deposition.

What is the most commonly encountered MR imaging feature of Aria-e?

The most commonly encountered MR imaging feature of ARIA-E at detection was a region of sulcal FLAIR hyperintensity in 78\% (28/36) of cases, referred to as ARIA-E effusion/exudate (Fig 1). Of these, 13 also had some degree of adjacent parenchymal FLAIR hyperintensity, with parenchymal involvement described as ARIA-E edema (Fig 2).