What is difference between intrinsic and extrinsic pathway?

The extrinsic pathway is activated by external trauma that causes blood to escape from the vascular system. The intrinsic pathway is activated by trauma inside the vascular system, and is activated by platelets, exposed endothelium, chemicals, or collagen.

What is extrinsic pathway of coagulation?

The extrinsic pathway consists of the transmembrane receptor tissue factor (TF) and plasma factor VII/VIIa (FVII/FVIIa), and the intrinsic pathway consists of plasma FXI, FIX, and FVIII. Under physiological conditions, TF is constitutively expressed by adventitial cells surrounding blood vessels and initiates clotting.

What does extrinsic pathway mean?

The extrinsic pathway of blood coagulation is also known as the tissue factor pathway and refers to a cascade of enzymatic reactions resulting in blood clotting and is done with the addition of injured tissue cells.

What does intrinsic pathway mean?

In molecular biology, the term intrinsic pathway may refer to multiple cascades of protein interactions. The intrinsic pathway of apoptosis refers to cell death initiated by changes in mitochondria, also known as the mitochondrial pathway or intracellular pathway or intrinsic apoptosis.

What is intrinsic coagulation pathway?

The intrinsic pathway consists of factors I, II, IX, X, XI, and XII. Respectively, each one is named, fibrinogen, prothrombin, Christmas factor, Stuart-Prower factor, plasma thromboplastin, and Hageman factor. The extrinsic pathway consists of factors I, II, VII, and X. Factor VII is called stable factor.

Why is it called extrinsic pathway of coagulation?

The pathway of blood coagulation activated by tissue factor, a protein extrinsic to blood, is known as the extrinsic pathway (Figure 1). Tissue factor serves as a cofactor with factor VII to facilitate the activation of factor X. Alternatively, factor VII can activate factor IX, which, in turn, can activate factor X.

What is extrinsic apoptotic pathway?

In molecular biology, the words extrinsic pathway may refer to both the extrinsic pathway of apoptosis and the extrinsic pathway of blood coagulation. Extrinsic apoptosis pathway is one of the signal pathways which may trigger the process of programmed cell death namely cell apoptosis. …

What is intrinsic apoptosis pathway?

Intrinsic pathway of apoptosis The intrinsic apoptosis pathway begins when an injury occurs within the cell. Intrinsic stresses such as oncogenes, direct DNA damage, hypoxia, and survival factor deprivation, can activate the intrinsic apoptotic pathway.

Why is extrinsic pathway called extrinsic?

What is the common pathway of coagulation?

Coagulation can be initiated through the activation of two separate pathways, designated extrinsic and intrinsic. Both pathways result in the production of factor X. The activation of this factor marks the beginning of the so-called common pathway of coagulation, which results in the formation of a clot.

What are intrinsic pathways?

What is Intrinsic Pathway. Intrinsic pathway refers to multiple cascades of protein interactions activated by a trauma inside the blood vessels. It is also activated by platelets, exposed endothelium, or collagen. Generally, intrinsic pathway takes time to form a blood clot.

What is intrinsic pathway?

In molecular biology, the term intrinsic pathway may refer to multiple cascades of protein interactions. The intrinsic pathway of apoptosis refers to cell death initiated by changes in mitochondria, also known as the mitochondrial pathway or intracellular pathway or intrinsic apoptosis.

What are clotting factors?

The clotting factors are a group of chemicals in the blood which is responsible for the formation of blood clot.

Clotting factors are usually inactive but once there is an injury to the wall of the blood vessel,they get activated.

The function of clotting factors is to trigger the formation of a blood clot and stabilize it for as long as necessary.