What is Ocusert used for?

BRAND NAME(S): Ocusert Pilo. USES: This medication reduces pressure in the eye. It is used to treat glaucoma.

What polymer is Ocusert?

Ocuserts were prepared using polymers pullulan, HPC, HPMC K4M, CMC, Na Alg., PVA and XG. The selection of polymers depended on their film-forming properties, their biodegradability and retardant to biodegradability to provide sustained release pattern.

How do ocular inserts work?

They offer several advantages as increased ocular residence and sustained release of medication into the eye. The insert includes a body portion sized to position within a lachrymal canaliculus of the eyelid. The inserts are classified according to their solubility as insoluble, soluble, or bioerodible inserts.

Which is a non erodible insert?

The Non-erodible ocular inserts include Ocusert, and Contact lens. In the bioerosion mechanism, the insert is comprised of a matrix of bioerodible material in which the drug is dispersed.

What does Latanoprost do for your eyes?

Latanoprost eye drops is used to treat certain kinds of glaucoma. It is also used to treat a condition called hypertension of the eyealone or together with other medicines to lower pressure inside the eye that is caused by open-angle glaucoma or ocular (eye) hypertension.

Which drug is used in Ocusert system?

• The rate of drug diffusion is controlled by: * The Ocusert therapeutic system is a flat, flexible, elliptical device designed to be placed in the inferior cul-de-sac between the sclera and the eyelid and to release Pilocarpine continuously at a steady rate for 7 days.

Which polymer is used for rate controlling membrane in Ocuserts?

A modified solvent casting method was used for the preparation of azithromycin insert in which hydroxyl propyl methyl cellulose (HPMC) and Eudragit RL100 were used as drug reservoir and rate controlling membrane respectively.

What is limitation of Tdds?

Common disadvantages of TDDS: 1,3-5 Many drugs especially drugs with hydrophilic structures permeate the skin too slowly may not achieve therapeutic level. 2. The drug, the adhesive or other excipients in the patch formulation can cause erythema, itching, and local edema.

What are the barriers in ocular drug delivery absorption?

Following systemic administration, the blood–aqueous barrier and blood–retinal barrier are the major barriers for anterior segment and posterior segment ocular drug delivery, respectively. Blood–aqueous barrier consists of two discrete cell layers located in the anterior segment of the eye viz.

Is a drug unsuitable for Grdds?

DRUGS THOSE ARE UNSUITABLE FOR GRDDS [21] 1. Drugs with low acidic solubility (e.g., phenytoin) 2. Drugs those are unstable or degrade in the acidic environment of the stomach (e.g., erythromycin) 3. Drugs those are used for targeted release in the colon (e.g., corticosteroids).

Does latanoprost cause weight gain?

Change in eyesight, eye pain, or very bad eye irritation. Shortness of breath, a big weight gain, or swelling in the arms or legs.

What are ocuserts and how do they work?

Ocuserts are plastic membranes about one-third the size of a contact lens. They are inserted into the eye and worn under the upper or lower lid where they cannot be seen. They contain pilocarpine, which is released slowly into the eye, and need to be changed every five days.

What are the disadvantages of Ocusert?

Some disadvantages encountered were need for instruction and encouragement of patients; retention difficulties, with some patients unaware when the device was lost; occasional side effects of a cutting sensation (as when the Ocusert sometimes doubles over), movement in the eye, and transient blurring of vision and miosis; and high cost.

What is the Ocusert pilocarpine system?

The Ocusert pilocarpine system: advantages and disadvantages Thirty-four patients with glaucoma were treated with the Ocusert pilocarpine system, a unique method of providing round-the-clock delivery of pilocarpine in the eye for seven-day periods.

What is Ocusert Pilo?

Pilocarpine is used to treat glaucoma and other eye conditions. This medicine is available only with your doctor’s prescription. Before using Ocusert Pilo In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do.