What is synthon give an example?

Example. In planning the synthesis of phenylacetic acid, two synthons are identified: a nucleophilic “COOH−” group, and an electrophilic “PhCH2+” group. In this case, the cyanide anion is the synthetic equivalent for the COOH− synthon, while benzyl bromide is the synthetic equivalent for the benzyl synthon.

What is illogical Synthon?

Disconnection of a bond of a target molecule gives positively charged (electrophilic) synthons where the normal polarity is reversed then the synthon is called an unnatural or illogical electrophilic synthon, and the corresponding synthetic equivalent is called illogical electrophilic synthetic equivalent or illogical …

What is FGI in chemistry?

FGI: Functional Group Interconversion: The operation of writing one functional group for another so that disconnection becomes possible. The reverse of a chemical reaction. – imaginary breaking of bonds (disconnections) and by the conversion of one functional group into another (functional group interconversions).

What is illogical synthon?

Why is retrosynthesis important?

Retrosynthesis in Achieving Synthesis of Complex Target Molecules. By beginning with the target molecule, retrosynthesis allows chemists to work “in reverse”, by breaking up the complex target structure to arrive at the simple precursors.

What is a synthetic equivalent?

Synthetic equivalent: A reagent carrying out the function of a synthon which cannot itself be used, often because it is too unstable. • Synthon: A generalized fragment, usually an ion, produced by a disconnection. (some people also use synthon for a synthetic equivalent).

What is Umpolung reagent?

The canonical umpolung reagent is the cyanide ion. The cyanide ion is unusual in that a carbon triply bonded to a nitrogen would be expected to have a (+) polarity due to the higher electronegativity of the nitrogen atom. This chemical ambivalence results in umpolung in many reactions where cyanide is involved.

What is a synthon in chemistry?

In retrosynthetic analysis, a synthon is a destructural unit within a molecule which is related to a possible synthetic operation. The term was coined in 1967 by E. J. Corey. He noted in 1988 that the “word synthon has now come to be used to mean synthetic building block rather than retrosynthetic fragmentation structures”.

When was synthon founded?

The company was founded in 1991 by two organic chemists of the Radboud University Nijmegen. Synthon is active in the Netherlands, the Czech Republic, Spain, the United States, Argentina, Chile, Russia, Mexico and South Korea with about 1,900 employees. The company is headquartered in Nijmegen.

What is a synthon in retrosynthetic analysis?

In retrosynthetic analysis, a synthon is a hypothetical unit within a target molecule that represents a potential starting reagent in the retroactive synthesis of that target molecule. The term was coined in 1967 by E. J. Corey.

Where is synsynthon based?

Synthon is active in the Netherlands, the Czech Republic, Spain, the United States, Argentina, Chile, Russia, Mexico and South Korea with about 1,900 employees. The company is headquartered in Nijmegen.